Metabolic phenotyping is an established systems biology tool that provides an integrated profile of an individual’s phenome, or the sum of its measurable traits that are defined by the dynamic and complex interactions of genes, epigenetics, symbiotic microorganisms, diet and non-sequence influences such as environmental exposures1. The ANPC utilizes cutting-edge analytical platforms including Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS) to generate high-fidelity information which are then fused and modelled using proprietary data architecture and informatic pipelines. The resulting phenotypic profiles of health, disease, environmental impact and latent pathobiology contains clinically actionable information that can lead to improved disease diagnosis and precision interventions, as well as inform healthcare management policies to further facilitate the personalization of patient journeys. The ANPC is closely linked to other phenome centres around the world that work closely together to create harmonized technology platforms. It is a metabolic discovery engine that provides Australia with a global edge in frontier science and medical technology.